Histologic and immunohistologic comparison between follicular and marginal zone lymphomas involving the spleen. Typical examples
of follicular lymphoma involving the spleen (A, H&E, ×100; B, CD21, ×100; C, CD10, ×100; D, HGAL, ×100; and E, LMO2, ×100) and splenic marginal zone lymphoma (F, H&E, ×100; G, CD23, ×100; H, CD10, ×100; I, HGAL, ×100; and J, LMO2, ×100) show predominantly white pulp expansion with a nodular growth pattern of the neoplastic infiltrates. The splenic
marginal zone lymphoma shows an expansion of the marginal zones, although the architectural differences may be subtle; the
follicular lymphoma shows retention of CD21+ follicular dendritic cell meshworks and expression of germinal center B cell–associated
markers CD10 and HGAL, whereas expression of these markers is absent in the splenic marginal zone lymphoma. LMO2 was absent
in both cases.